The Regente Hotel is located within walking distance of Plaza Mayor. The hotel offers convenient access to the historic Los Austrias area of the city. Puerta del Sol is also within walking distance of the hotel. The Regente Hotel is located along the city metro line. The metro, along with rental cars and taxis, offers easy access to points of interest and attractions throughout Madrid, as well as the airport, which is located near the hotel.

All of the guestrooms at the Regente Hotel include air conditioning. There are 153 rooms on offer, and each offers a television, desks, direct dial phones, and more. Private bathrooms with bidets and hair dryers are also offered in each guestroom.

There are numerous shops and restaurants within easy reach of the hotel. Guests will find that there are daily excursions on offer, as well as a buffet breakfast. The hotel also offers a currency exchange, ticket services, dry cleaning, and private parking.